lmp1 protein

Epstein–Barr virus latent membrane protein 1 (LMP1) is an Epstein–Barr virus (EBV) protein that regulates its own expression and the expression of human genes. It has a molecular weight of approximately 63 kDa, and its expression induces many of the changes

DNA: Herpes simplex, Herpes simplex virus

Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF

5/2/2017 · Toll-like receptor 7 stimulates the expression of Epstein-Barr virus latent membrane protein 1 LMP1 TRAF binding site was required for LMP1-mediated autoantibody production, the germinal center response to immunization, and optimal production of several

29/10/2018 · Kieser A(1)(2), Sterz KR(3). Author information: (1)Helmholtz Center Munich-German Research Center for Environmental Health, Munich, Germany. [email protected] (2)German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. [email protected] (3

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Epstein-Barr virus is a human herpesvirus that causes infectious mononucleosis and lymphoproliferative malignancies. LMP1 (latent membrane protein-1), which is encoded by this virus and which is essential for transformation of B lymphocytes, acts as a

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LMP1 10 results for LMP1 Sort by Clear all Done Filters Product types Clear Primary antibodies Mouse monoclonal [CS1, CS2, CS3, CS4] to EBV Latent Membrane Protein 1, prediluted Application: IHC-Fr, IHC-P Conjugate: Unconjugated Recombinant EBV

23/1/2018 · Epstein–Barr virus (EBV) drives human B cell proliferation and transformation, but also potent T cell surveillance. When surveillance fails, EBV-driven malignancies arise. T cells can be stimulated/expanded on EBV-transformed B cells for adoptive therapy. Clinical

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30/9/2005 · Abstract Epstein-Barr virus is a human herpesvirus that causes infectious mononucleosis and lymphoproliferative malignancies. LMP1 (l atent m embrane p rotein-1), which is encoded by this virus and which is essential for transformation of B

This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1)

Aliases: TRAF3, CAP-1, CAP1, CD40bp, CRAF1, IIAE5,

Abstract Epstein-Barr virus is a human herpesvirus that causes infectious mononucleosis and lymphoproliferative malignancies. LMP1 (l atent m embrane p rotein-1), which is encoded by this virus and which is essential for transformation of B

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Thorley-Lawson, 2009; Roughan et al, 2010). In contrast, in EBV-associated lymphomas such as Hodgkin’s disease, AIDS-related lymphomas and post-transplant lymphoproliferative disease, LMP1 is always expressed in proliferating infected cells and the protein is

Thank you for contacting Abcam. I have tried blasting the human EBV-LMP1 sequences against the rhesus monkey database and I cannot seem to get a hit for the rhesus EBV sequence (the only hit is for unnamed protein product, #21103, which has a 70%

2/7/2019 · Epstein-Barr virus (EBV) latent membrane protein-1 (LMP1) activates numerous signal transduction pathways using its C-terminal activating regions. We reported that LMP1 increased global levels of sumoylated proteins, which aided the oncogenic nature of LMP1. Because increased protein

9/7/2007 · The oncogene latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) without a ligand drives proliferation of EBV-infected B cells. Its levels vary in cells of clonal populations by more than 100-fold, which leads to multiple distinct activities of the oncogene. At

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LMP1 protein is a ligand-independent,constitutivelyactive,oncogenicsignalingmolecular,butitsroleinviral pathogenesis and its potential effects on the viral life cycle have not been fully elucidated(12,13). As a double-stranded DNA virus, EBV genome sequences are

15/10/2007 · The Epstein-Barr virus (EBV) protein LMP1 is considered to be a functional homologue of the CD40 receptor. However, in contrast to the latter, LMP1 is a constitutively active signaling molecule. To compare B cell–specific LMP1 and CD40 signaling in an

18/6/2010 · Epstein-Barr virus (EBV)-encoded LMP1 protein is commonly expressed in nasopharyngeal carcinoma (NPC). LMP1 is a prime candidate for driving tumourigenesis given its ability to activate multiple signalling pathways and to alter the expression and activity of

Almost exactly twenty years after the discovery of Epstein-Barr virus (EBV), the latent membrane protein 1 (LMP1) entered the EBV stage, and soon thereafter, it was recognized

19/1/2018 · cells and nasopharyngeal carcinoma cells. Our findings indicate that EBV-encoded latent membrane protein 1 (LMP1), which lacks an RIP homotypic interaction motif (RHIM) domain, has mechanisms distinct from RHIM signaling competition to

Almost exactly twenty years after the discovery of Epstein-Barr virus (EBV), the latent membrane protein 1 (LMP1) entered the EBV stage, and soon thereafter, it was recognized

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NF-kB-mediated transcriptional upregulation of TNFAIP2 by the Epstein–Barr virus oncoprotein, LMP1, promotes cell motility .9,10 LMP1 is an integral membrane protein with a short N-terminus, six

Abstract The latent membrane protein 1 (LMP1) of the Epstein-Barr virus is a constitutively active receptor essential for B lymphocyte transformation by the Epstein-Barr virus. It is a short-lived protein

Loss-of-function mutations in genes encoding the signaling protein tumor necrosis factor receptor–associated factor 3 (TRAF3) are commonly found in human B-cell malignancies, especially

Pool of 94 peptides derived from a peptide scan through Latent membrane protein 1 (LMP1) of Epstein-Barr virus (HHV4) for T cell assays Company About us History Team Technologies Quality

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in the Carcinogenesis of Nasopharyngeal Carcinoma Hui Zheng1, Lili Li1, Duosha Hu1, Xiyun Deng1 and Ya Cao1, 2 Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) has been known to

LMP1 protein expression detected in tumor nests of a canine oral amelanotic melanoma. (A) A control tumor section that stained negative for LMP1 protein signal (counterstained in purple). (B) An LMP1

High impact information on LMP-1 CONCLUSIONS: LMP1-mediated signaling through the TRAF system has a role in the pathogenesis of the EBV-positive lymphomas that arise in immunosuppressed patients . The latent membrane protein 1 (LMP1

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Immune Surveillance and Therapy of Lymphomas Driven by Epstein-Barr Virus Protein LMP1 in a Mouse Model Baochun Zhang,1,11 Sven Kracker,1,6,11 Tomoharu Yasuda,1,7,11 Stefano

9/7/2010 · The latent membrane protein-1 (LMP1) encoded by Epstein-Barr virus (EBV) is an oncoprotein which acts by constitutive activation of various signalling pathways, including NF-κB. In

Epstein–Barr virus (EBV) was the first human virus found to encode microRNAs (miRNAs), but the function of these miRNAs has been obscure. Nasopharyngeal carcinoma (NPC) is associated with EBV infection, and the EBV-encoded LMP1 is believed to be a key

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brane protein LMP1 in type I BLs. Three of them could also be upregulated in the human keratino-cyte cell line RHEK-1 by LMP1 transfection. This upregulation was paralleled by the LMP1-induced increase in vimentin expression in both cell types. One of thej

Epstein-Barr virus (EBV) was the first human virus found to encode microRNAs (miRNAs), but the function of these miRNAs has been obscure. Nasopharyngeal carcinoma (NPC) is associated with EBV infection, and the EBV-encoded LMP1 is believed to be a key

If activation of NF-κB mediated by the TRAF proteins and transformation ability of the LMP1 protein were coupled to identical pathways, a strong correlation between the data obtained from these two functional assays would be expected. However, this could not

Flow (Intracellular): EBV Latent Membrane Protein 1 Antibody (LMPO24) [NBP2-50383] – Intracellular staining of LMP1 using LMPO24 antibody. There are no reviews for EBV Latent Membrane Protein 1 Antibody (NBP2-50383). By submitting a

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Immune Surveillance and Therapy of Lymphomas Driven by Epstein-Barr Virus Protein LMP1 in a Mouse Model Baochun Zhang,1,11 Sven Kracker,1,6,11 Tomoharu Yasuda,1,7,11 Stefano Casola,1,2,8,11 Matthew Vanneman,3 Cornelia Ho¨mig-Ho¨lzel,2,9 Zhe Wang,1

9/7/2019 · Latent membrane protein 1 (386 aa, ~42 kDa) is encoded by the Epstein-Barr virus LMP1 gene. This protein is involved in both the activation of nuclear factor-kappa-B family signaling pathways and the inhibition of apoptosis of infected B-lymphocytes.

Objective:To express structural GST-LMP-1 fusion protein in E.coli,detecting and analyzing its antibodies in NPC patients’ sera of EBV associated malignancies with Western-blot. Methods:The plasmid pMD18-LMP1 containing the recombinant extracellular peptide

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protein 1 (EBV-LMP1, a well-documented onco-protein of EBV) , is reported to induce DNA methylation by up-regulating DNMT1 expression [10, 11]. Positive LMP1 expression was significantly associated with poorer overall survival in nasopharyngeal carcinoma

14/5/1998 · Epstein–Barr virus (EBV) is associated with various malignant and benign lymphoproliferative disorders. It also efficiently transforms human B lymphocytes in vitro. The latent membrane protein 1 (LMP1) of EBV-infected cells plays a central part in this process by mimicking members of the family of